Abstract: 10.10 Inhibition Of Gdf8 (Myostatin) Enhances Bone Healing In Murine Diabetic Bone
نویسندگان
چکیده
introduCtion: The healing capacity of bone can be substantially reduced by metabolic diseases such as diabetes mellitus. Apart from an epidemiological component of metabolic diseases the present poor therapy of diabetic associated bone healing deficiencies demands adequate new treatment options. In previous studies we were able to show a massive impairment of bone regeneration in diabetic bone. In a recent study the protein GDF8 (Myostatin) known for the role in muscle catabolism is significantly involved in bone metabolism. The goal of this study is to investigate the role of GDF8 in diabetic bone healing. As a next step we seek to utilize GDF8 inhibitors (Follistatin) to enhance bone healing in diabetic bones.
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